Your healthcare provider will advise you if you should take gabapentin while breastfeeding. Do not share gabapentin with other people, even if they have the same condition as you. Gabapentin may also be used for other conditions as determined by your healthcare provider. Inform your providers of all medications you take, including prescription and over-the-counter, as well as supplements, vitamins and herbal products. Gabapentin is available as both a brand name product and whippets balloons a generic product (chemically the same, usually lower cost than the brand name product).
The potential for alteration in hydrocodone exposure and effect should be considered when NEURONTIN is started or discontinued in a patient taking hydrocodone. Other drugs are available to treat your condition; some may be better suited for you than others. If your doctor decides to reduce your dose or have you stop taking gabapentin, they will do this slowly.
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However, looking across studies, a trend toward increasing efficacy with increasing dose is evident (see Figure 4). One study compared NEURONTIN 1200 mg/day, in three divided doses with placebo. Responder rate was 23% (14/61) in the NEURONTIN group and 9% (6/66) in the placebo group; the difference between groups was statistically significant. Response ratio was also better in the NEURONTIN group (-0.199) than in the placebo group (-0.044), a difference that also achieved statistical significance. The reduction in weekly mean pain scores was seen by Week 1 in both studies, and were maintained to the end of treatment.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Follow all directions on your prescription label and read all medication guides or instruction sheets. Some people have thoughts about suicide while taking seizure medicine.
- The right dosage will vary depending on the condition a person has and several other factors.
- The most frequently reported reactions were anxiety, insomnia, nausea, pain, and sweating.
- This document does not contain all possible side effects and others may occur.
- Tell your healthcare provider if you develop severe sleepiness, especially when you start gabapentin or when your dose is increased.
- When used with gabapentin, opioids can cause dangerous effects in the body.
Evidence of effectiveness was obtained in three trials conducted in 705 patients (age 12 years and above) and one trial conducted in 247 pediatric patients (3 to 12 years of age). In patients continuing to have at least 2 (or 4 in some studies) seizures per month, NEURONTIN or placebo was then added on to the existing therapy during a 12-week treatment period. A zero value indicates no change while complete elimination of seizures would give a value of -1; increased seizure rates would give positive values. A response ratio of -0.33 corresponds to a 50% reduction in seizure frequency. The results given below are for all partial seizures in the intent-to-treat (all patients who received any doses of treatment) population in each study, unless otherwise indicated.
The risk for serious problems such as severe dizziness and sleepiness may be increased if you drink alcohol while taking gabapentin. Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if gabapentin is right for you. For gabapentin oral liquid, use an accurate measuring device to measure your dose.
Risk of overdose
Pharmacokinetic differences due to race have not been studied. Because gabapentin is primarily renally excreted and there are no important racial differences in creatinine clearance, pharmacokinetic differences due to race are not expected. NEURONTIN is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients. It is not known whether gabapentin has the ability to increase cell proliferation in other cell types or in other species, including humans. Antiepileptic drugs should not be abruptly discontinued because of the possibility of increasing seizure frequency.
The effect of age was studied in subjects 20–80 years of age. Apparent oral clearance (CL/F) of gabapentin decreased as age increased, from about 225 mL/min in what is smack in the dirt those under 30 years of age to about 125 mL/min in those over 70 years of age. Renal clearance (CLr) and CLr adjusted for body surface area also declined with age; however, the decline in the renal clearance of gabapentin with age can largely be explained by the decline in renal function. see DOSAGE AND ADMINISTRATION and Use In Specific Populations. Include information that the risk is greatest for those using concomitant CNS depressants (such as opioid analgesics) or those with underlying respiratory impairment. Teach patients how to recognize respiratory depression and advise them to seek medical attention immediately if it occurs see WARNINGS AND PRECAUTIONS.
Risk of suicidal thoughts or behaviors
The maximum time interval between doses should not exceed 12 hours. The recommended maintenance dose of NEURONTIN is 300 mg to 600 mg three times a day. Dosages up to 2400 mg/day have been well tolerated in long-term clinical studies. Doses of foods that contain alcohol 3600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. Administer NEURONTIN three times a day using 300 mg or 400 mg capsules, or 600 mg or 800 mg tablets.
The maximum time between doses should not exceed 12 hours. Gabapentin capsules, tablets, and oral solution are used along with other medications to help control certain types of seizures in people who have epilepsy. Gabapentin capsules, tablets, and oral solution are also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles).
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